在一般人群中基于简单健康检查的临床和尿液参数对临床意义上的瘤查:多中心机器学习研究
Hao-Wei Chen1,2,3, Pei-Siou Wei4,5, Yu-Chen Chen1,2,6
1Department of Urology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.
JMIR medical informatics
|February 19, 2026
概括
一个新的机器学习模型使用常规临床数据有效地选结石. 这种非侵袭性方法有助于早期检测和管理,改善了结石病患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 人工智能的人工智能
- 医学诊断 医学诊断 医学诊断
背景情况:
- 结石病影响15%的人口,在无症状的个体中往往未被发现.
- 目前的成像诊断是昂贵的,取决于操作人员,或涉及辐射.
- 需要一个实用,低成本的查结石的查策略.
研究的目的:
- 开发一种低成本,快速查的模型,用于临床上显著的结石病.
- 使用机器学习 (ML) 和简单的临床参数来早期检测结石.
主要方法:
- 在台湾3家医院 (2012-2021) 接受6528名成年人的回顾性研究.
- 训练有素的ML模型使用10个常规变量,包括人口统计,病史和尿液分析.
- 使用ROC和PR曲线评估的模型;Shapley价值分析用于可解释性.
主要成果:
- 最好的ML模型实现了0.968的AUC和0.936.93的AUPRC.
- 在结石检测方面表现出高灵敏度 (87.3%) 和特异性 (94.7%).
- 确定了关键预测因素:尿液红细胞计数,估计的膜过率和尿液特异性重力.
结论:
- 开发了一种高效的非侵入性ML模型,用于大规模结石查,使用常规健康数据.
- 模型可以整合到健康检查和远程医疗中,以进行主动管理.
- 建议在不同人群中进一步验证,以确保可通用性.
相关概念视频
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
459
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
459
Urinary Tract Calculi III: Medical Management
290
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
290
Urinary Tract Calculi I: Introduction
598
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
598
Urinary Tract Calculi VI: Surgical Management
619
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
619
Urinary Tract Calculi V: Nursing Management
348
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
348
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
458
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
458


