工程自激活的聚合物纳米酶精确地消灭与瘤相关的细胞内菌,以基于分化集群的潜在免疫疗法 47 阻断

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Yunjian Yu^1,2, Jialu Bai^1,2, Juntao Fan^1,2

¹State Key Laboratory of Advanced Separation Membrane Materials & Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes (MOE) & Tianjin Key Laboratory of Hollow Fiber Membrane Materials and Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China.

|February 19, 2026

概括

工程纳米酶针对结直肠癌巨细胞中的Fusobacterium nucleatum,重编程免疫环境并提高免疫疗法的有效性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
材料科学材料科学材料科学

背景情况:

结肠直肠癌 (CRC) 免疫疗法受到免疫抑制瘤微环境的阻碍.
Fusobacterium nucleatum (Fn) 通过感染巨细胞并驱动M2极化来促进这种免疫抑制.

研究的目的:

为了设计一种能够消除巨细胞内Fn储存器的纳米酶.
重新编程巨细胞的免疫生态系统,并增强CRC免疫疗法.

主要方法:

开发了具有铁素和甲酸盐 (AS) 有效载荷的可自我激活的聚合物纳米酶.
通过曼诺斯受体介导的内细胞分裂,向Fn感染的M2巨细胞.
利用细胞内过氧化用于纳米酶激活,芬顿化学和ROS生成.

主要成果:

纳米酶释放铁离子和AS,放大ROS杀死细胞内Fn.
阿特苏纳酸诱导了自,增强了纳米酶-细菌的局部化和Fn杀死.
消除Fn逆转了M2免疫抑制,并促进了邻近巨细胞的M1复极化.
在CRC模型中,纳米酶增强了抗CD47免疫疗法的疗效.

结论:

工程纳米酶有效地消除了CRC中的内巨细胞Fn.
这一策略重塑了瘤免疫格局,克服了免疫抑制.
这种方法对改善结肠直肠癌免疫疗法充满希望.

关键词:

结肠直肠癌是什么意思免疫疗法免疫疗法细胞内 Fusobacterium核核细胞内聚合物纳米酶是一种多重分子.与瘤相关的巨细胞.

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