造成阿芬坦西亚的病变与状图像节点相连
Julian Kutsche1, Calvin Howard2, Alberto Castro Palacin3
1Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Berlin School of Mind and Brain, Department of Philosophy, Humboldt-Universität zu Berlin, Berlin, Germany.
概括
幻觉,无法在精神上想象,与大脑功能有关. 导致获得的阿芬塔西亚的病变连接到左侧状图像节点,这对视觉心理图像至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经成像是一种神经成像.
背景情况:
- 幻觉错觉 (Aphantasia),即先天性缺少视觉心理图像,影响着高达3%的人口.
- 正确的脑区底层的幻觉和视觉心理图像仍然在很大程度上是未知的.
- 由于大脑病变而导致的获得性幻觉症为视觉心理图像的神经解剖学提供了一个独特的窗口.
研究的目的:
- 为了确定获得的幻觉症的神经解剖学相关性.
- 研究状图像节点在视觉心理图像中的作用.
- 建立特定大脑区域与视觉心理图像能力之间的因果关系.
主要方法:
- 系统的文献审查,以确定病变诱导的花症病例.
- 将损伤映射到普通的大脑图谱上,并与对照病变进行比较.
- 使用静止状态fMRI数据分析损伤部位和状成像节点之间的功能连接.
- 数据驱动的全脑病变连接性分析,用于敏感性和特异性.
主要成果:
- 鉴定了12例由于脑损伤而导致的获得性幻觉病例.
- 损伤位置虽然多样化,但始终显示出与左侧状成像节点的功能连接.
- 与状图像节点的连接是幻想症的敏感和特定标记.
结论:
- 获得的阿芬塔西亚是由于大脑各个区域的病变造成的,但所有病变都与左侧状图像节点功能相关.
- 这项研究为状图像节点在视觉心理图像中的关键作用提供了因果证据.
- 这些发现有助于我们更好地理解视觉心理图像和幻觉的神经基础.
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