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Updated: Feb 21, 2026

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ATP调节生物材料:设计策略和医疗应用

Xiuyun Xu1, Zeying Wang1, Ting Wu2

  • 1Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry, Ministry of Health, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081, P.R. China; Institute of Advanced Clinical Medicine, Peking University, 100191, Beijing, China.

Biomaterials
|February 19, 2026
PubMed
概括

响应或调节腺三酸盐 (ATP) 的生物材料为治疗与能量失衡相关的疾病提供了新的途径. 本综述对这些ATP调节材料进行了分类,并讨论了它们的治疗潜力.

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In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
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ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
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