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微塑料相关的肠道微生物概况和学龄前儿童的抗生素耐药性:中国的一项多中心横截面研究

Xinyuan Liu¹, Hua Cai², Long Zhao³

¹School of Public Health, Institute of Nutrition, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China; Quzhou Center for Disease Control and Prevention, Quzhou, China.

|February 19, 2026

概括

幼儿园儿童接触微塑料 (MP) 可能会改变肠道细菌和功能,可能会增加抗生素耐药性. 需要进一步的研究来了解年轻人群中的这些风险.

科学领域:

环境科学环境科学
微生物学微生物学
公共卫生公共卫生

背景情况:

微塑料 (MP) 是生态系统和人体中普遍存在的环境污染物.
人类暴露水平和影响,特别是对肠道微生物群的影响,仍然在很大程度上未得到量化.
众所周知,MPs是抗生素耐药性基因 (ARG) 的载体,但它们在ARG丰富性中的作用尚未得到充分研究.

研究的目的:

为了调查学龄前儿童的微塑料暴露.
评估微塑料暴露与人类肠道微生物群的组成和功能之间的关联.
探索便样本中微塑料存在与抗生素耐药基因之间的关系.

主要方法:

一项多中心的横截面研究,涉及中国学龄前儿童的335个便样本 (2022年10月 - 2023年3月).
使用热解气体染色学/质谱法 (Py-GC/MS) 进行微塑料分析.
通过16S rRNA和元基因组测序对肠道微生物群进行分析.

主要成果:

检测到八种类型的MPs,其中位数度为212.1μg/g dw.
MP存在与肠道微生物群组成的改变和62个代谢途径的丰富有关.
总塑料度与物种和ARG丰度相关,尽管与特定的塑料聚合物无关.

结论:

这项研究提供了对学龄前儿童的MP暴露的初步数据,表明可能会破坏肠道细菌群落和功能.
这些发现引发了人们对不良健康影响的担忧,包括增加抗生素耐药性的风险,特别是在幼儿中.
需要进一步的研究,以阐明MP暴露对人类肠道健康的确切机制和长期影响.

关键词:

我们的肠道微生物群.高通量测序的高通量测序微塑料是一种微塑料.幼儿园幼儿园幼儿园的孩子在Py-GC/MS中使用.

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