人类新生儿下丘脑的基于MRI的结构发展
Elizabeth Yen1, Josepheen De Asis-Cruz2, Jerod M Rasmussen3
1Tufts University School of Medicine, Boston, MA, USA; Woman, Mother + Baby Research Institute, Tufts Medical Center, Boston, MA, USA; Tufts Medicine Pediatrics-Boston Children's, Boston, MA, USA.
Developmental cognitive neuroscience
|February 19, 2026
概括
早期的脑部发育表明,下丘脑随着年龄的增长而增大,但母亲吸烟与体积较小有关,其影响持续到青春期. 了解这些早期变化是长期健康的关键.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 放射学 放射学是指放射学
背景情况:
- 宫内暴露可能会影响早期的大脑发育和未来的健康风险.
- 下丘脑调节重要的早期生命功能,如睡眠,生长和新陈代谢.
- 有限的人类数据存在于早期的下丘脑结构发育及其影响因素.
研究的目的:
- 描述新生儿下丘脑体积的规范性发育.
- 调查子宫内暴露,特别是妊娠年龄和母亲吸烟对下丘脑体积的影响.
- 评估这些关联在青春期持续存在的程度.
主要方法:
- 使用了631名新生儿的发展人类连接体项目 (dHCP) 的T1加权MRI扫描.
- 分析了下丘脑体积和月经后年龄 (PMA),性别和妊娠年龄 (GA) 之间的关联.
- 研究了孕妇在怀孕期间吸烟的影响,并在青少年队列中验证了研究结果 (ABCD研究).
主要成果:
- 下丘脑体积在PMA时增加,但在调整为大脑总体积时没有增加.
- 男性的绝对体积较大,但相对下丘脑体积较小.
- 较低的妊娠年龄 (GA) 与较大的相对下丘脑体积有关,以性别为调节.
- 怀孕期间母亲吸烟与新生儿下丘脑体积较小有关,显示剂量依赖.
- 这些与吸烟有关的差异持续到青春期.
结论:
- 生命早期的下丘脑体积发育受到规范性生长和子宫内暴露的影响.
- 怀孕期间母亲吸烟是与下丘脑体积减少相关的重要因素,持续影响到青春期.
- 这些发现强调了下丘脑对产前环境的脆弱性及其对长期健康的影响.
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