患有婴儿发作综合征的儿童的长期结果:韩国的一项多中心回顾性研究
Sun Ah Choi1, Minhye Kim2, Hye Jin Kim3
1Department of Pediatrics, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
Clinical and experimental pediatrics
|February 19, 2026
概括
婴儿发作综合征 (IESS) 是一种严重的疾病,导致慢性和认知障碍. 大多数儿童需要持续服用药物,许多儿童患有耐药性和智力障碍.
科学领域:
- 儿科神经学 儿科神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 发育神经科学的发展神经科学.
背景情况:
- 婴儿发作综合征 (IESS) 是婴儿的一种严重综合征.
- 它与显著的长期发病率和受影响的儿童和家庭的高负担有关.
研究的目的:
- 评估IESS儿童的长期和神经发育结果.
- 根据近几十年的管理策略评估结果.
主要方法:
- 一项回顾性多中心研究包括了在1994年至2021年期间被诊断患有IESS的378名婴儿.
- 收集的数据包括人口统计,临床特征,诊断和治疗.
- 结果在至少2年的随访后进行评估.
主要成果:
- 获得的结构性病因是最常见的 (29.9%). 结核性硬化综合体和唐氏综合征是常见的遗传原因.
- 维加巴是主要治疗方法 (93.9%). 在随访时,77.8%的人仍在服用抗发作药物,29.1%的人患有耐药性.
- 大约90%的人有智力障碍,其中一半接受特殊教育.
结论:
- IESS导致慢性和认知功能受损,造成相当大的负担.
- 韩国临床实践需要共识的诊断和治疗指南,以确保早期诊断和及时干预.
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