健康的日本儿童的尿道微生物组与年龄相关的变化
Uuganbayar Gonchigsuren1, Shoji Tsuji1, Shohei Akagawa1
1Department of Pediatrics, Kansai Medical University, Osaka, Japan.
Journal of pediatric urology
|February 19, 2026
概括
儿科尿道微生物组 (urobiome) 经历了显著的年龄和性别特定的变化,在青春期后达到成人状况. 这项研究为儿童健康发育建立了基线,这对于了解泌尿病状况至关重要.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 人的泌尿道包含一个复杂的微生物群体 - - 沙巴基组,其在儿童中的发展尚不清楚.
- 建立儿科基线对于识别与尿路感染和尿液浸泡等疾病相关的微生物失生症至关重要.
- 这项研究将地理和种族的多样性添加到一些研究中,重点关注健康的日本儿科队列.
研究的目的:
- 在健康的日本儿童的尿道微生物组中,以特定年龄和性别的发育变化为特征.
- 为了比较儿科的成体组与成人的成体组.
主要方法:
- 从93名健康儿童和60名成年人中收集了中流尿液,分为四个年龄组.
- 使用16S rRNA基因测序 (V3-V4) 分析细菌组成.
- 评估的α多样性 (香农,Chao1) 和β多样性 (布雷-库蒂斯,PCoA).
主要成果:
- 在男性中,微生物多样性在较年轻的儿童 (3-5岁) 中比较高.
- 在女性中,在青春期后,多样性显著下降,乳酸菌和双菌的增加.
- 在女性青春期左右观察到明显的组成变化,成年男性与儿科组不同.
结论:
- 儿科骨干组显示动态,多阶段的成熟受年龄和性别的影响.
- 雌性体在青春期以增加的乳酸菌稳定后,而雄性成熟更为缓慢.
- 这些发现为正常的儿科皮肤瘤发育建立了基线,有助于诊断与失生症相关的疾病.
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