自组装的8-shogaol/curcumin纳米粒子通过键:增强稳定性和持续释放 in vitro
Rui Zhang1, Jing-Yu Feng1, Kiran Thakur2
1School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China.
Food chemistry
|February 19, 2026
概括
研究人员开发了新型的黄素/聚乙烯 (PVP) /8-shogaol纳米粒子 (PCS-NP),以改进8-shogaol.
科学领域:
- 材料科学和纳米技术
- 制药科学 制药科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 8-Shogaol是一种生物活性化合物,具有不良的可溶性和稳定性,限制了其治疗应用.
- 基于纳米粒子的药物输送系统提供了一个有前途的策略来克服这些局限性.
研究的目的:
- 为了合成和表征黄素/聚乙烯 (PVP) /8-shogaol纳米颗粒 (PCS-NP),以增强8-shogaol输送.
- 研究开发的纳米粒子的稳定性,释放动力学和肠道运输.
主要方法:
- 通过键自组装合成PCS-NP.
- 使用传输电子显微镜 (TEM),富里埃变换红外光谱 (FTIR) 和H NMR进行表征.
- 评估颗粒大小,泽塔潜力,封装效率,负载能力,稳定性,释放和肠道运输.
主要成果:
- 优化的PCS-NP显示颗粒大小为82.58nm,泽塔电位为-22.4mV,封装效率为81.4%,负载能力为15.08%.
- PCS-NP 显示出优越的储存稳定性和对温度和紫外线辐射的适应性.
- 观察到增强了8-shogaol的肠道释放和运输效率.
结论:
- PCS-NP有效地提高了8-shogaol的可溶性,稳定性和生物可访问性.
- 这项研究为利用PCS-NP作为8-shogaol的药物输送系统提供了理论基础.
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