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Bifidobacterium infantis和B. longum的基因组图谱提供了婴儿益生菌设计的信息
Yan Shao1, Shuyi Wang1, Bonface M Gichuki2
1Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Cell
|February 19, 2026
概括
商用益生菌菌株如Bifidobacterium longum和B. infantis可能不适合所有婴儿. 全球基因组图谱显示,B. infantis在低收入国家很常见,这表明需要适合地理位置的益生菌.
科学领域:
- 微生物组研究的研究.
- 基因组学就是基因组学.
- 益生菌 益生菌 益生菌
背景情况:
- Bifidobacterium longum和B. infantis是关键的早期肠道殖民者和常见的益生菌.
- 目前的商业益生菌通常来自高收入国家 (HIC),可能不适合低收入和中等收入国家 (LMIC) 的婴儿.
研究的目的:
- 创建一个全面的全球基因组图谱的Bifidobacterium物种.
- 研究B. longum和B. infantis的基因组多样性和地理分布.
- 为了帮助开发地理上合适的益生菌菌株.
主要方法:
- 来自48个国家的4000多个Bifidobacterium基因组组合.
- 高分辨率的基因组学和功能分析.
- 比较基因组学以确定适应当地饮食和环境的适应性.
主要成果:
- 确认B. longum和B. infantis是不同的物种,具有不同的功能和流行率.
- B. infantis 在LMIC的早期生命微生物群中普遍存在,但在HIC中很少见.
- 自然B. infantis菌株表现出显著的地理分层和适应当地饮食和母乳成分.
结论:
- 已经建立了一个全球基因组资源Bifidobacterium,增加了LMICs的代表性.
- 在B. infantis的地理变化表明需要特定位置的益生菌选择.
- 该资源可以指导针对不同婴儿种群的精密益生菌和微生物群治疗方法的开发.
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