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Updated: May 5, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

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转录抑制剂Fli1在营养压力期间抑制蛋白质稳定,以限制NK细胞在固体瘤中的持久性

Jeong Hyun Ji1, Wesley R Armstrong2, Joey H Li2

  • 1Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.

Immunity
|February 19, 2026
PubMed
概括

瘤透的自然杀手 (NK) 细胞由于瘤微环境中蛋白质的积累而变得功能障碍. 准FLI1可能会恢复NK细胞的抗瘤活性.

关键词:
在Fli1上.功能障碍 功能障碍是指一种功能障碍.代谢 代谢 代谢 代谢自然杀手细胞是自然杀手细胞.蛋白质聚合物的蛋白质聚合物.蛋白质稳定症是一种蛋白质稳定症.固体瘤是一种固体瘤.瘤间歇性液体 瘤间歇性液体瘤微环境是一个微环境.不折叠的蛋白质反应反应

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