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Updated: Aug 17, 2026

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准AARS1-依赖乳化可以改善神经元过程的可塑性,并减轻败血症相关脑病变的认知缺陷

Shiyuan Luo1, Zhuochen Lyu1, Hongjun Huang1

  • 1Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Brain, behavior, and immunity
|February 19, 2026
PubMed
概括

在败血症相关脑病变 (SAE) 中的乳酸积累通过ATRIP的AARS1-介导乳化损伤神经元. 在SAE小鼠模型中,L-alanine或ATR抑制恢复了认知功能,提供了潜在的治疗点.

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