用于重度抑郁症的LSD微剂量:来自2a期试验的情绪和药理动力学结果
Dimitri Daldegan-Bueno1, Carina Joy Donegan2, Rachael Sumner1
1School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand.
Progress in neuro-psychopharmacology & biological psychiatry
|February 19, 2026
概括
这项研究发现,在8周的时间里,微量服用lysergic acid diethylamide (LSD) 改善了抑郁症患者的情绪. 重复的微剂量并没有导致耐受性或敏感性,这表明潜在的治疗益处.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的临床试验证据证明微剂量迷幻药物存在.
- 人们越来越感兴趣于微剂量 lysergic acid diethylamide (LSD) 治疗心理健康状况.
- 大型抑郁症 (MDD) 影响着相当一部分人群.
研究的目的:
- 为了研究8周微剂量LSD治疗对情绪和抑郁症严重性的影响.
- 为了评估下语言微剂量LSD的药理学.
- 评估对效应的主观感知,并确定潜在的耐受性或敏感性.
主要方法:
- 一项涉及19名患有多重抑郁症的参与者的开放试验.
- 参与者接受了16次语言下LSD剂量,从8微克开始,并定位至20微克.
- 每日情绪和抑郁症严重程度使用视觉模拟量表 (VAS) 和汉密尔顿抑郁症评分量表 (HAMD6) 进行评估.
- 使用非分区和分区建模分析了药理动力学.
主要成果:
- 每日VAS在剂量日表示情绪相关状态 (例如,创造力,快乐) 的增加 (p=0.009到0.039).
- 没有观察到抑郁症严重程度的显著降低 (p=0.291).
- 没有证据表明对重复的LSD微剂量有耐受性或敏感性 (p>0.081).
- 估计了药理动力学参数 (AUC0-tlast,Cmax,Tmax) 的估计.
结论:
- 微剂量LSD可能会导致抑郁症患者的短期情绪改善.
- 这项研究在压缩样本中提供了8微克LSD的药理动力学数据.
- 进一步的受控试验是有必要的,以证实这些发现,并探索治疗潜力.
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