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细胞外囊泡通过Nrf2 / GPX4介导的ferroptosis抑制来改善子宫内粘附

Qin Xiao¹, Leiping Ding², Xilong Zhang³

¹Departments of Reproductive Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China; The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.

Journal of advanced research

|February 19, 2026

概括

来自Lactobacillus crispatus NCU-28的细胞外囊泡 (EVs) 通过Nrf2/GPX4通路调节铁亡,通过Nrf2/GPX4通道调节铁亡,从而减少子宫内粘附 (IUA) 模型中的炎症和纤维化,从而提供新的治疗策略.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
生殖生物学生殖生物学

背景情况:

益生菌利用细胞外囊泡 (EVs) 作为疾病过程中的功能调解者.
阴道益生菌衍生的EVs在子宫内粘附 (IUA) 的作用尚不清楚.

研究的目的:

为了识别来自 Lactobacillus crispatus NCU-28.8. 的 EVs.
阐明这些EV的抗炎和抗纤维机制.

主要方法:

从L. crispatus NCU-28中分离出了EVs. 这些EV是从L. crispatus NCU-28中分离出来的.
使用IUA小鼠和炎症细胞模型进行评估.
利用高通量测序和分子生物学技术.

主要成果:

来自L. crispatusNCU-28的EV显示出抗炎和抗纤维作用.
EV治疗降低了纤维化标志物 (α-SMA,TGF-β1) 和促炎细胞因子 (IL-6,IL-1β) 的调节.
通过Nrf2 / GPX4激活,EVs调节铁亡,抑制氧化应激并促进子宫内膜修复.

结论:

EVs是L. crispatusNCU-28的关键功能组成部分,用于改善IUA.
通过调节铁亡,EVs具有抗炎和抗纤维作用.
这些发现支持开发基于益生菌EV的IUA治疗方法.

关键词:

细胞外囊泡中的细胞外囊泡.铁性化 (ferroptosis) 是一种宫内粘附在子宫内粘附.乳酸细菌有状状.Nrf2/GPX4信号通路的使用情况

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