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在CKD中基线和纵向自我报告的身体功能和心脏结局之间的关系:来自CRIC研究的发现
Vanessa-Giselle Peschard1, Wei Yang2, Xiaoming Zhang2
1Kidney Health Research Collaborative, San Francisco VA Healthcare System and University of California San Francisco, San Francisco, CA & Eledon Pharmaceuticals, Research and Development, MA.
概括
慢性病 (CKD) 的身体功能下降与心力衰竭和死亡率的更高风险有关. 早期干预以保持身体功能可以预防不良的心脏和脏结局.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
背景情况:
- 身体功能对于独立和健康至关重要.
- 它在慢性病 (CKD) 中的发展轨迹和对结果的影响还未得到充分研究.
- 自我报告的身体功能是监测患者健康的关键指标.
研究的目的:
- 检查基线和纵向自我报告的身体功能与慢性脏病患者心脏和脏结局的关联.
- 确定身体功能是否预测心力衰竭,末期脏疾病和死亡率.
- 为潜在的干预措施提供信息,旨在保护CKD患者的身体功能.
主要方法:
- 来自慢性功能不全队列 (CRIC) 研究的参与者的前性队列研究.
- 利用物理组件总结 (PCS) 评分和PCS斜率来测量身体功能.
- 采用多变量调整的考克斯回归模型来分析关联,控制共变量.
主要成果:
- 较低的基线PCS得分与发生性心力衰竭 (HF) 和全因死亡率的风险增加有关.
- 降低PCS分数 (PCS斜率) 独立地与发生性HF,全因死亡率和发生性末期病 (ESKD) 的更高风险有关.
- 在完全调整后,关联仍然很重要,突出了身体功能的预测价值.
结论:
- 基线和纵向的身体功能与慢性脏病的不良心脏和脏结局有显著的关联.
- 这些发现强调了监测慢性病患者的身体功能的重要性.
- 针对身体功能维护的干预措施可能对改善这一群体的长期健康结果至关重要.
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