在小鼠味蕾中追踪Twist2表达细胞的血统
Namiki Takaku-Tanoue1, Kae Matsuyama2, Takashi Toyono3
1Division of Orofacial Functions and Orthodontics, Department of Health Promotion, Kyushu Dental University, 2-6-1 Manazuru, Kitakyushu, 803-8580, Kokurakita-ku, Japan; Division of Anatomy, Department of Health Promotion, Kyushu Dental University, 2-6-1 Manazuru, Kitakyushu, 803-8580, Kokurakita-ku, Japan.
Journal of oral biosciences
|February 19, 2026
概括
中细胞有助于味蕾的形成. 这项研究使用了小鼠的谱系追踪来表明,Twist2表达性介质细胞分化为II型和III型味觉受体细胞.
科学领域:
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
- 感官生物学 感官生物学
背景情况:
- 味蕾细胞传统上被认为起源于上皮.
- 新出现的证据表明,一些味蕾细胞的产生源于介质细胞.
- 转录因子Twist2的特异性表达在味蕾中介质成分中.
研究的目的:
- 研究Twist2表达介质细胞对味蕾发育的贡献.
- 描述Twist2衍生细胞在味蕾中的生物特性.
主要方法:
- 使用了Twist2谱系追踪记者小鼠 (Twist2-Cre与tdTomato交叉).
- 进行了免疫组织化学分析和味道器官培养.
- 使用5-乙烯基-2'-脱氧氨 (EdU) 标签评估细胞增殖和持久性.
主要成果:
- Twist2衍生 (tdTomato阳性) 细胞表达型III味觉细胞标记物.
- 来自介酶体细胞的味觉器官含有大量的味蕾细胞.
- EdU分析表明Twist2衍生型III味觉细胞的长期持久性,有机体显示分化为II型味觉细胞.
结论:
- 表达Twist2的介质细胞有助于味蕾细胞群.
- 这些发现支持味蕾细胞的双重起源 (上皮和介质细胞).
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