喉喉损伤对感觉性吞反射的影响
Naoyuki Mitarai1, Chihiro Nakatomi2, Chia-Chien Hsu2
1Division of Physiology, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, 803-8580, Japan; Division of Endodontics and Restorative Dentistry, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, 803-8580, Japan.
Journal of oral biosciences
|February 19, 2026
概括
喉喉损伤损害了水的吞能力,但通过TRPV1通道增强了素引起的吞能力. 这表明,由于TRPV1基因表达的增加,受伤后的感觉反射是明显的,并且可能被促进.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 生理学 生理学 生理学
背景情况:
- 已知喉损伤会损害水引起的吞.
- 这种损伤对由疼痛 (nociceptive) 刺激触发的吞反射的影响尚不清楚.
研究的目的:
- 研究喉损伤如何影响依赖于感觉受体的吞反射.
- 确定TRPV1和TRPA1通路在这些反应中的作用.
主要方法:
- 成年雄性大鼠使用内镜吞评估进行了研究.
- 吞是由水,素 (TRPV1激动剂) 和酸 (AITC,TRPA1激动剂) 输注引发的.
- 使用酸诱导了喉喉损伤,并分析了相关质中TRPV1和TRPA1的基因表达.
主要成果:
- 伤害抑制了水引起的吞,但增强了素引起的吞,降低了敏感性.
- AITC延长了吞延迟时间,但没有改变吞次数.
- 在受伤后的石骨/关节复合体中,TRPV1基因表达显著上调.
结论:
- 与水相比,无感受刺激会激活不同的吞机制.
- 喉喉损伤可能会通过TRPV1-依赖的通路促进素引起的吞.
- 在特定的神经中增加TRPV1表达似乎是这些促进反应的基础.
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