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在肝病中便微生物群移植:治疗潜力和相关风险

Jayeeta Bhowmick¹, Arka Bagchi¹

¹Department of Gastroenterology, All India Institute of Medical Sciences Kalyani, Basantpur, Nadia, West Bengal, India.

Progress in molecular biology and translational science

|February 19, 2026

概括

便微生物种移植 (FMT) 对肝硬化与肝脏脑病变等肝脏疾病有希望,改善了结果. 对与酒精相关的肝炎和MASLD/MASH需要进一步的研究,在肝病学中使用FMT需要监管.

科学领域:

胃肠病学和肝病学
微生物组研究微生物组研究
翻译医学是一种翻译医学.

背景情况:

肠肝轴在肝脏疾病的发病过程中起着至关重要的作用.
便微生物种移植 (FMT) 是一种调节肠道微生物群的策略.
目前关于各种肝脏疾病中FMT的证据正在合成.

研究的目的:

审查肝脏疾病中FMT的证据和实践.
探索FMT在肝硬化,酒精相关性肝炎,MASLD/MASH和慢性乙型肝炎中的疗效.
讨论标准化方法和FMT在肝病学中的未来方向.

主要方法:

来自随机试验和早期阶段研究的现有证据的综合.
分析FMT对临床结果,微生物组合和宿主生理学的影响.
对标准化FMT方法的审查,包括供体查和制造.

主要成果:

FMT在肝硬化和肝脑病变中显示出辅助益处,改善认知和减少复发.
早期的试验表明,FMT可能会减少感染,并改善与酒精相关的严重肝炎的短期生存率.
在MASLD/MASH中,FMT改变了肠道透性和胆酸概况,但并没有持续改善关键的代谢标志物.

结论:

对于特定的肝脏疾病,特别是HE,FMT是一种有前途的治疗策略.
需要进一步严格的多中心研究来证实酒精相关性肝炎和MASLD/MASH的益处.
标准化的协议,精确的供体匹配和监管监督对于肝病学中安全有效的FMT至关重要.

关键词:

一个阿尔德.便微生物群移植便微生物群移植肝发性脑病变是一种肝发性脑病变.肝脏疾病肝脏疾病马斯尔德马斯尔德是什么意思这是NAFLD.

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