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不同的遗传特征会影响婴儿和青少年之间的体重指数
Geng Wang1, Samuel McEwan2, Jian Zeng2
1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. geng.wang@uq.edu.au.
Nature communications
|February 19, 2026
概括
遗传因素影响从童年到青春期的体重指数 (BMI) 轨迹. 体重指数 (BMI) 的遗传性随着年龄的增长而变化,在发育阶段有着不同的遗传影响.
科学领域:
- 人类遗传学 人类遗传学
- 发育生物学是发展生物学.
- 生物统计学 生物统计学
背景情况:
- 身体质量指数 (BMI) 在整个人类发展过程中表现出动态变化.
- 众所周知,BMI的遗传贡献因年龄而异.
- 了解这些年龄不同的遗传影响对于解决儿童肥胖至关重要.
研究的目的:
- 研究1至18岁BMI轨迹的遗传贡献.
- 量化BMI的遗传性及其在发育过程中的变化速度.
- 探索BMI在不同发育阶段的遗传相关性.
主要方法:
- 使用随机回归模型 (RRM) 方法.
- 分析了来自6,291名ALSPAC参与者的数据,其中65,930人重复测量了BMI.
- 估计基于SNP的遗传性和BMI轨迹的遗传相关性.
主要成果:
- 基于SNP的BMI在9.5年的遗传率估计为28.4%.
- 从1岁到18岁的BMI变化率的遗传率为23.8%.
- 在早期儿童和青春期的BMI之间观察到较低的遗传相关性 (0.108).
- 主要成分分析揭示了影响BMI轨迹的两大遗传变异轴.
结论:
- 随机回归模型有效地揭示了在整个发育过程中对BMI的年龄特定遗传影响.
- 对BMI轨迹的遗传影响从童年到青春期的幅度增加.
- 不同的遗传因素在早期和晚期发育期影响BMI.
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