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Updated: Jun 9, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

酸化Runx蛋白控制助手CD4+T细胞与细胞毒性CD8+T细胞谱系选择

Chihiro Ogawa1, Kazuki Okuyama1, Satoshi Kojo1,2

  • 1Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, Japan.

Nature immunology
|February 19, 2026
PubMed
概括

T细胞谱系的承诺依赖于基因沉默. 像Lck和Zap70这样的激酶的Runx1酸化通过启用Cd4和Thpok基因沉默来驱动细胞毒性T细胞分化.

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Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice05:03

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