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Updated: May 2, 2026

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一个1294个无血细胞DNA甲基组和碎片组的泛癌综合,使得多种癌症的检测成为可能

Yong Zeng1, Dor D Abelman2,3, Althaf Singhawansa2

  • 1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Yong.Zeng@uhn.ca.

Nature cancer
|February 19, 2026
PubMed
概括

这项研究引入了一种统一的计算方法来分析无细胞DNA甲基化和碎片化. 这种方法增强了对多种癌症类型的微创性癌症检测和亚型监测.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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