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在前列腺炎模型中通过低强度的体外冲击波疗法通过整合素-β1 / NRF2轴抑制铁亡
Dongxu Lin1, Kang Li1, Wenbo Kuang1
1Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The world journal of men's health
|February 20, 2026
概括
低强度体外冲击波疗法 (Li-ESWT) 通过减少炎症和纤维化,缓解慢性前列腺炎/慢性骨盆疼痛综合征 (CP/CPPS). 这种疗法通过Integrin-β1/NRF2通路缓解铁亡,一种细胞死亡形式.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物医学工程 生物医学工程
- 细胞生物学 细胞生物学
背景情况:
- 慢性前列腺炎/慢性盆腔疼痛综合征 (CP/CPPS) 影响许多人,对治疗机制的理解有限.
- 低强度体外冲击波疗法 (Li-ESWT) 是CP/CPPS的临床选择,但其潜在的分子途径尚未完全阐明.
研究的目的:
- 研究由Li-ESWT激活的机械传导信号通路.
- 在CP/CPPS模型中探索Li-ESWT和铁亡之间的关联.
- 澄清整合素β1/NRF2通路在Li-ESWT治疗效果中的作用.
主要方法:
- 通过前列腺抗原免疫诱导的实验性自身免疫性前列腺炎 (EAP) 鼠标模型.
- 治疗组包括Li-ESWT,铁死诱导剂 (RSL3) 和铁化剂 (DFO).
- 在体外研究LPS刺激的RWPE-1细胞与调节的整合素-β1/NRF2-xCT/GPX4轴.
主要成果:
- -ESWT显著缓解了EAP症状,减少了炎症,纤维化和过敏症.
- -ESWT抑制了氧化应激和铁亡标志物,包括减少的活性氧物种,铁和脂质过氧化.
- 观察到Integrin-β1 / NRF2-xCT / GPX4通路的激活,这对于Li-ESWT的抗ferroptotic作用至关重要.
结论:
- 在动物模型中,Li-ESWT有效地改善了CP/CPPS病理.
- -ESWT的治疗效益通过通过Integrin-β1/NRF2信号通路缓解铁.
- 这项研究提供了关于Li-ESWT用于CP/CPPS治疗的机制性见解.
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