结合运动,抗炎药物和饮食建议 (MMIEAD) 的多模式综合干预,用于患有硬性的成年人:混合方法可行性集群,随机对照试验和过程评估的协议
Joanne Reid1, Carolyn Blair2, Adrian Slee3
1School of Nursing and Midwifery, Queen's University Belfast, Belfast, UK. j.reid@qub.ac.uk.
Pilot and feasibility studies
|February 20, 2026
概括
这项研究评估了慢性病 (CKD) 患者硬化多模式干预的可行性. 这些发现将为更大的运动,抗炎药物和饮食建议的试验提供信息,以改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床试验 临床试验
- 实施科学 实施科学
背景情况:
- 晚期慢性病 (CKD) 的严重并发症硬症,涉及体重减轻和肌肉消耗,显著影响患者的生活质量.
- 目前对硬化的干预措施不足,突出显示需要可实施的策略.
- 该研究通过评估多模式,综合,运动,抗炎和饮食建议 (MMIEAD) 干预来解决这一差距.
研究的目的:
- 评估MMIEAD干预措施的可行性,可接受性和上下文适应性,用于血液透析依赖性CKD患者.
- 为了确定患者的资格,招募率和干预的坚持.
- 评估最终经济评估的可行性,并为未来的大规模试验提供信息.
主要方法:
- 一种混合方法方法,涉及12周可行性集群随机对照试验 (cRCT) 在4个英国血液透析单位.
- 与患者和医疗保健从业人员 (HCP) 进行定性过程评估,以评估可接受性和实用性.
- 为最终的经济评估进行可行性评估.
主要成果:
- 该研究将确定MMIEAD干预的患者资格标准和招募率.
- 它将确定CKD患者的干预保留和坚持水平.
- 将评估研究设计和数据收集的关键统计和方法考虑因素.
结论:
- 在高级CKD中,MMIEAD干预措施对治疗脏缓解症有前途.
- 关于可行性,可接受性和上下文适应性的证据将使用PRISM/RE-AIM框架生成.
- 这些发现将为最终的全英国多站点cRCT做准备.
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