在东帝汶的医院环境中对抗性优先病原体携带的横截面调查 2020-2021 东帝汶 2020-2021 东帝汶
Sarah A Lynar1,2,3, A Vieira4, A D K Draper4,5,6
1Menzies School of Health Research, Charles Darwin University, Dili, Timor-Leste. sarah.lynar@nt.gov.au.
抗微生物耐药性是一种全球性威胁. 东帝汶发现ESBL,西普罗夫洛克萨和甘他米辛耐药性高,而MRSA和卡巴胺耐药性低,需要持续监测.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球重大健康挑战.
- 世界卫生组织 (WHO) 通过全球抗微生物耐药性和使用监测系统 (GLASS) 识别了关键的AMR病原体.
- 东帝汶已经提高了其诊断能力,使得AMR监测成为可能.
研究的目的:
- 对东帝汶的住院和门诊患者进行AMR的横截面监测研究.
- 确定关键耐药生物体的流行率,包括生产格拉姆阴性细菌的黄金葡萄球菌 (MRSA) 和扩展光谱β-乳糖酶 (ESBL).
- 评估耐药性与人口或环境因素之间的关联.
主要方法:
- 在2020-2021年,东帝汶所有医院进行了一项横截面研究.
- 抽样被培养为S. aureus (包括MRSA) 和ESBL产生生物体.
- 测试了S. aureus,大肠杆菌和Klebsiella pneumoniae的分离物,以检测其对西普罗夫洛克萨和热胺素的耐药性;进行了单变量和多变量分析.
主要成果:
- 黄金菌的流行率为18.0% (MRSA为2.7%).
- 产生ESBL的有机体的患病率为21.1%,其中21.3%对西普罗夫洛克萨辛有耐药性,15.1%对珍塔米辛有耐药性.
- 在迪利观察到对ESBL,西普罗洛克萨和热因素的更高耐药率;住院病人的身份与热因素耐药性有关;拥有狗对ESBL运输.
结论:
- 携带ESBL,西普罗洛克萨和珍塔米辛耐药性的携带率很高,特别是在迪利.
- 甲基西林耐药金黄色细菌 (MRSA) 携带和抗卡巴胺耐药性较低.
- 持续监测AMR对于监测趋势和指导治疗准则至关重要.
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