在男女中使用IGF-PAPP-A-Stanniocalcin轴和雄激素合成类固醇
Laust Frisenberg Buhl1,2,3, Louise Lehmann Christensen1,2,3, Yeliz Bulut4,5
1Department of Endocrinology, Odense University Hospital, Odense, Denmark.
European journal of endocrinology
|February 20, 2026
概括
类固醇类固醇 (AAS) 使用会改变类似胰岛素的生长因子 (IGF) 系统,影响心血管健康. 在AAS停止后,IGF-2,IGFBP-3和STC2的这些性别特异性变化仍然存在.
科学领域:
- 内分泌学 在内分泌学.
- 心血管生理学心血管生理学
- 运动医学 运动医学
背景情况:
- 类固醇类固醇 (AAS) 是一种具有潜在内分泌作用的性能增强药物.
- 胰岛素类生长因子 (IGF) 系统在生长和新陈代谢中起着至关重要的作用.
- 以前的研究表明AAS和IGF系统之间存在联系,但性别特异性的影响尚不清楚.
研究的目的:
- 为了比较男性和女性休运动员的IGF系统,当前或过去的AAS使用者与非用户相比.
- 为了研究因AAS暴露而导致IGF系统潜在的性别特异性变化.
- 探索与AAS相关的IGF系统变化和心血管参数之间的关联.
主要方法:
- 对80名活跃的阿斯使用者,26名前使用者和58名非使用者 (包括男性和女性参与者) 的横截面研究.
- 临床检查,心声学和循环IGF-1,IGF-2,IGF生物活性,IGF结合蛋白 (IGFBPs),与怀孕相关的血蛋白-A (PAPP-A) 和-A2 (PAPP-A2),以及斯坦尼奥卡尔-1 (STC1) 和-2 (STC2) 的测量.
- 统计分析调整了各种混因素,包括年龄,性别,身体组成,生活方式和训练史.
主要成果:
- 与以前的用户和非用户相比,活跃的AAS用户显示IGF-2和IGFBP-3水平显著降低.
- 在使用AAS的男性中,STC2水平升高,但女性没有.
- 累积的AAS暴露与改变的IGF-2,IGFBP-3和STC2水平相关.
- 较高的IGF-2和IGFBP-3与良好的心脏功能有关,而较高的STC2与不良的心血管结果相关.
结论:
- 非法使用AAS导致IGF-PAPP-A-STC2轴的持续性,性别特异性失调.
- 这些变化可能会导致休运动员心血管风险增加.
- 这些发现强调了考虑IGF系统的重要性,以了解AAS使用的长期健康后果.
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