多囊卵巢综合征和干眼疾病:系统性审查和元分析
Moumi Maity1, Marlies Gijs2, Reiko Arita3
1Brien Holden Eye Research Center (BHERC), LV Prasad Eye Institute, Hyderabad, Telangana, India.
Current eye research
|February 20, 2026
概括
患有多囊性卵巢综合征 (PCOS) 的女性可能会出现轻微的眼睛干燥症状,但她们的眼膜稳定性和体积与健康个体相当. 由于证据的确定性较低,需要进一步研究.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,影响生殖年龄的女性.
- 干眼病 (DED) 是一种普遍的眼部疾病,具有多因素的原因.
- 由于潜在的共享病理生理机制,PCOS和DED之间的关系需要进行调查.
研究的目的:
- 与健康对照人群相比,对患有PCOS的女性进行一项元分析,评估干眼症状和催膜参数.
- 综合现有关于眼表面疾病指数 (OSDI) 评分,眼膜分解时间 (TBUT),Schirmer值和PCOS中的meibography的证据.
主要方法:
- 在PubMed,Cochrane图书馆和Scopus进行了系统的文献搜索,寻找相关的前性和横截面研究.
- 包括的研究比较了PCOS患者的催膜参数或干眼症状与健康对照.
- 使用RevMan软件进行了元分析,计算了加权平均差异 (MD),并通过GRADE评估证据确定性.
主要成果:
- 分析了13项涉及639名PCOS患者的研究.
- 患有PCOS的女性的OSDI分数明显降低 (MD 7.5) 和侵袭性TBUT (MD -3.1s).
- 施尔默I值和非侵入性TBUT显示PCOS和对照组之间没有显著差异,所有参数的证据确定性低.
结论:
- 虽然患有PCOS的女性可能会报告轻微的干眼症状,但他们的目标眼体积和膜稳定性通常与非PCOS个体相似.
- 目前的证据表明,PCOS中的膜参数通常不符合DED的诊断标准,尽管研究异质和确定性低.
- 建议进一步进行高质量的研究,以澄清PCOS和干眼疾病之间的关联.
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