[研究临床血液测试参数作为心房动的潜在预测因素]
A G Plisyuk1, P P Poletskov1, E A Zhdanova1
1Lomonosov Moscow State University.
Terapevticheskii arkhiv
|February 20, 2026
概括
常规血液检查可以预测心房动 (AF). 较高的中性粒细胞与淋巴细胞比率 (NLR) 和较低的淋巴细胞与单细胞比率 (LMR) 表明,无论其他健康状况如何,AF风险都增加了.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 炎症研究 炎症研究
背景情况:
- 心房动 (AF) 是一种常见的心律失常.
- 慢性系统性炎症越来越被认为是导致心血管疾病的一个因素.
- 识别AF可访问的预测因子对于早期干预至关重要.
研究的目的:
- 调查常规血液检查中的炎症标志物与AF存在之间的关联.
- 确定计算的炎症指数是否可以作为AF的预测指标.
主要方法:
- 对5041名患者的回顾性分析.
- 倾向性得分匹配以创建可比的AF和非AF组 (每组470名患者).
- 临床血液测试参数和炎症指数的比较,包括ROC分析和后勤回归.
主要成果:
- 患有AF的患者表现出更高的中性粒细胞,单细胞和不成熟的粒细胞数量,以及炎症指数的升高.
- 在AF组中观察到较低的淋巴细胞计数和LMR.
- SIRI>1.3和LMR>4.84是显著的预测指标,分别增加AF几率2.13倍和减少2.27倍.
结论:
- 慢性系统性炎症的生物标志物与AF存在有关,不依赖年龄,性别或并发症.
- 常规血液检测炎症标志物显示出AF检测预测工具的潜力.
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