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相关概念视频

Stereoisomerism02:52

Stereoisomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Stereoisomers02:32

Stereoisomers

On the basis of mirror symmetry, stereoisomers of an organic molecule can be further classified into diastereomers and enantiomers. Diastereomers are stereoisomers that are not mirror images of each other. Substituted alkenes, such as the cis and trans isomers of 2-butene, are diastereomers, as these molecules exhibit different spatial orientations of their constituent atoms, are not mirror images of each other, and do not interconvert. Here, the interconversion is suppressed due to restricted...
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
Radical Halogenation: Stereochemistry01:33

Radical Halogenation: Stereochemistry

Stereochemistry is the study of the different spatial arrangements of atoms in a given molecule. The stereochemistry of radical halogenations can be understood from three different situations:
Halogenation to form a new chiral center:

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相关实验视频

Updated: Jul 1, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

对超出四级协调范围的立体中心的控制.

Anton Budeev1, Christof Sparr1

  • 1Department of Chemistry, University of Basel St. Johanns-Ring 19 Basel 4056 Switzerland christof.sparr@unibas.ch.

Chemical science
|February 20, 2026
PubMed
概括

五坐标和六坐标立体性中心提供复杂的立体异构,超出了传统的双重立体性. 本综述探讨了它们在药物化学和催化等多个领域的合成和应用.

科学领域:

  • 立体化学是一种立体化学.
  • 主组和过渡金属化学的主要组和过渡金属化学.

背景情况:

  • 传统的立体性中心通常是四重协调的,具有双重立体性.
  • 五坐标和六坐标立体中心表现出更复杂的立体异构,扩大了可访问的立体化学空间.
  • 这种复杂的立体异构体在主要组和过渡金属化合物中观察到具有特定连接体.

研究的目的:

  • 总结五坐标和六坐标立体中心中高阶立体性的基本原理.
  • 为这些复杂的立体异构体提供新兴应用的概述.
  • 讨论具有更高阶立体中心的化合物的立体选择性合成策略.

主要方法:

  • 文献综述侧重于五坐标和六坐标中心的立体化学.
  • 在主组和过渡金属复合体中的立体异构的分析.
  • 探索用于立体选择性合成的合成方法.

主要成果:

  • 五坐标和六坐标中心可以编码多个立体异构体,与四坐标中心不同.
  • 这种复杂的立体异构在各种主要组和过渡金属化合物中普遍存在.
  • 这些中心的立体选择合成领域尚未得到充分探索,但具有显著的潜力.

结论:

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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

相关实验视频

Last Updated: Jul 1, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
07:50

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

Published on: May 26, 2019

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

  • 在五坐标和六坐标中心的更高阶立体性提供了扩大的立体化学可能性.
  • 这些中心在药物化学,催化和信息科学方面有着潜在的应用.
  • 进一步探索它们的立体选择合成是有必要的,以释放它们的全部潜力.