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Updated: May 13, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 27, 2016

异多普罗林作为用于晚期骨干修改的多功能工具

Karen D Milewska1,2, Brett D Schwartz1,2, Jemimah R Canning1,2

  • 1Research School of Chemistry, Australian National University Canberra ACT 2601 Australia lara.malins@anu.edu.au.

Chemical science
|February 20, 2026
PubMed
概括

这项研究引入了新的异型伪, thiazolidine-2-carboxylic 酸 (2-Thz) 和 selenazolidine-2-carboxylic 酸 (2-Sez),用于的设计. 这些残留物使得通过减小环开放的晚期脊柱修饰成为可能,从而产生多样化的类衍生物.

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An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis06:19

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Protein Modifications in the RER01:26

Protein Modifications in the RER

Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.