综合的多omics分析揭示了肠-大脑轴在自闭症儿童的参与
Hongping Zhong1,2, Shuyue Zhang1,3, Zichao Mou1,3
1Clinical School of Pediatrics, Tianjin Medical University, Tianjin, China.
Frontiers in microbiology
|February 20, 2026
概括
在MUC基因家族中的遗传缺陷会损害患有自闭症谱系障碍 (ASD) 的儿童的肠道屏障完整性,改变肠道微生物组并导致肠道问题. 这突显了宿主基因作为与ASD相关的肠-大脑轴功能障碍的关键驱动因素.
科学领域:
- 遗传学 是一个遗传学.
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 自闭症谱系障碍 (ASD) 通常与胃肠道 (GI) 问题和肠道失调有关.
- 宿主基因在与ASD相关的肠道微生物组改变中的作用尚不清楚.
研究的目的:
- 调查上游宿主遗传因素影响ASD的肠道失调.
- 整合多omics数据,以了解宿主基因和微生物群在ASD中的相互作用.
主要方法:
- 在ASD儿童和对照儿童的整体外体测序组合,16S rRNA基因测序和血代谢学.
- 进行了罕见变异丰富分析和多omics集成.
主要成果:
- 在ASD中确认了肠道微生物失调和代谢干扰,与胃肠道症状严重程度相关.
- 鉴定了MUC基因 (素生物合成) 中有害变异的丰富,对肠道屏障完整性至关重要.
- 在MUC途径中的宿主遗传缺陷与有益细菌的枯竭和粘素降解剂的扩张有关,影响脂质和SCFA代谢.
结论:
- 在MUC途径中的宿主遗传脆弱性损害了粘膜的完整性,重塑了ASD的肠道微生物组.
- 确定了罕见有害的MUC基因变异,作为ASD中肠-大脑轴功能障碍的上游驱动因素.
- 这些发现为ASD的精确干预提供了潜在的遗传点.
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