与免疫疗法相关的心血管毒性:从机制到管理
Lifeng Xiao1, Weitong Liu2, Yanchen Ji3
1Department of Emergency, Cancer Hospital of Shantou University Medical College, Shantou, China.
Frontiers in pharmacology
|February 20, 2026
概括
癌症免疫疗法如检查点抑制剂和CAR-T细胞可以引起心脏问题. 本综述涵盖了它们的心血管毒性,机制和管理策略,以获得更好的患者结果.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 免疫治疗不良事件 免疫治疗不良事件
背景情况:
- 癌症免疫疗法已经改变了瘤治疗.
- 心血管毒性是这些疗法的一个重要问题.
研究的目的:
- 审查与癌症免疫治疗相关的心血管毒性.
- 探索机制,风险分层,监测和管理.
- 讨论心脏瘤学的未来方向.
主要方法:
- 关于心血管不良事件的综合文献综述.
- 对病理生理机制的分析.
- 评估当前的管理和监测策略.
主要成果:
- 与免疫疗法相关的心血管毒性包括心肌炎,心周病,心律失常和心力衰竭.
- 机制包括T细胞交叉反应和细胞因子释放综合征.
- 有效的管理需要风险分层,监测和多学科的护理.
结论:
- 积极主动的心脏瘤学方法是必不可少的.
- 缓解心血管风险对于安全使用免疫疗法至关重要.
- 未来的研究应该专注于新的目标和先进的监测.
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