术后尼古丁治疗术后疼痛和恶心:一个系统性审查与临床和方法学的见解
Feras Twfeq Almogbel1, Mohammed Ali Alghamdi2, Ali Mohamed Elkarouri3
1Dammam Medical Complex, Nephrology Clinical Pharmacy Consultant, Dammam, Saudi Arabia.
Anesthesiology and pain medicine
|February 20, 2026
概括
术后尼古丁可以减少术后疼痛和阿片类药物使用,但其对术后恶心和吐 (PONV) 的影响是不一致的. 需要进一步的研究来澄清尼古丁的含量.
科学领域:
- 麻醉学和外科手术期间的医学.
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 尼古丁的潜在止痛特性和抗效应得到了认可.
- 之前对尼古丁治疗术后疼痛和恶心/吐 (PONV) 的研究已经产生了不一致的结果.
- 显然,需要对外科手术期间尼古丁的影响进行全面审查.
研究的目的:
- 系统地审查和综合有关术后尼古丁给药用于术后疼痛控制的证据.
- 评估术前尼古丁对术后恶心和吐 (PONV) 的影响.
- 评估尼古丁在术后期对阿片类药物消费的影响.
主要方法:
- 在PubMed,CENTRAL和谷歌学者 (2004-2023) 的系统文献搜索.
- 皮科标准:在全身麻醉下的患者,外科期间的尼古丁干预,安慰剂/无尼古丁控制,疼痛得分为主要结果.
- 11项研究 (753名参与者) 的研究结果的叙述综合,使用柯克兰风险偏见2工具.
主要成果:
- 包括11项涉及753名参与者的研究,涉及不同的手术程序,尼古丁输送方法和剂量.
- 在一些研究中,外科手术期间的尼古丁给药显示了术后疼痛,恶心,吐和阿片类药物消费的潜在减少.
- 研究之间的显著异质性阻止了进一步的子组分析.
结论:
- 术后尼古丁在改善术后疼痛管理和减少阿片类药物需求方面表现有前途.
- 尼古丁对术后恶心和吐 (PONV) 的影响仍然不一致,需要仔细考虑.
- 研究群体,尼古丁剂量和配方的变化限制了最终的临床建议.
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