相关实验视频
Updated: May 9, 2026

09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
血清神经纤维光链和疾病修饰治疗作为多发性硬化症认知衰退的预测因素
Vera Taluntiene1, Natasa Giedraitiene1, Rasa Kizlaitiene1
1Clinic of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Frontiers in neurology
|February 20, 2026
概括
血清神经丝水平可能表明多发性硬化症 (MS) 的早期认知衰退. 更高效的疾病修饰疗法 (DMT) 在保护MS患者的认知能力下降方面表现有前途.
科学领域:
- 神经免疫学 神经免疫学
- 神经学 神经学
- 神经科学是一个神经科学.
背景情况:
- 认知障碍 (CI) 在多发性硬化症 (MS) 中很常见,影响患者在疾病的早期.
- 早期发现和监测CI对于预防进一步的认知衰退和指导治疗策略至关重要.
研究的目的:
- 研究MS (PwMS) 患者的认知衰退和神经纤维光链 (NfL) 水平之间的关联.
- 在PwMS中探索认知衰退,残疾措施和不同类型的疾病修饰治疗 (DMT) 之间的关系.
主要方法:
- 一项前性研究涉及64名PwMS和14名健康对照.
- 在脑脊液 (CSF) 和血清中测量NfL水平.
- 使用MS简要国际认知评估 (BICAMS) 的认知评估和使用EDSS,9-HPT和T25FWT的残疾评估在基线和12个月后续.
主要成果:
- 与对照组相比,PwMS表现出较高的血清NfL (sNfL) 基线水平,在随访时正常化.
- 符号数字模式测试 (SDMT) 是唯一一个在PwMS随访时显著下降的BICAMS子测试.
- 基线和随访时的sNfL水平预测了SDMT下降,与高效的DMT相比,平台DMT与SDMT下降风险增加有关.
结论:
- 血清NfL显示出作为MS早期认知衰退的生物标志物的潜力.
- 在MS管理的早期启动高效的DMT可能会提供对认知能力下降的保护.
相关概念视频
Neural Regulation
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer's Disease: Treatment
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

