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经手术的免疫检查点抑制剂与激进囊切除术相结合:快速系统性审查和元分析

Navid Roessler^1,2, Marcin Miszczyk^1,3, Keiichiro Miyajima^1,4

¹Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

European urology open science

|February 20, 2026

概括

外科手术期间的免疫检查点抑制剂 (ICI) 与激进囊切除术 (RC) 结合,对肌肉侵入性膀癌 (MIBC) 是有前途的. 需要进一步的研究来优化这种多模式治疗的患者选择和治疗策略.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
尿路细胞癌是什么意思

背景情况:

肌肉侵入性膀癌 (MIBC) 治疗正在发展.
术后免疫检查点抑制剂 (ICI) 与激进囊切除术 (RC) 结合是一种新兴的策略.
优化MIBC的结果是一个关键的临床目标.

研究的目的:

综合有关术后ICI在接受RC的MIBC患者的疗效和安全性的证据.
评估与这种联合治疗方法相关的生存结果和不良事件.

主要方法:

随机对照试验 (RCT) 的快速审查和元分析.
在 MEDLINE,Embase,Web of Science 和 ESMO 摘要中进行了搜索.
分析了使用随机效应模型的生存数据和≥3级不良事件.

主要成果:

经手术的ICI显示出低通道泌尿道癌 (LTUC) 的无事件和整体存活率的潜在益处.
仅添加剂的ICI显示在LTUC中改善了无病存活率.
与仅使用辅助剂的ICI相比,在术后ICI中观察到≥3级不良事件的更高率.

结论:

术后ICI在接受RC的MIBC患者中显示出有希望的疗效.
试验设计和治疗策略的异质性限制了最终的解释.
优化患者选择,测序和组合策略对于MIBC多模式治疗的成功至关重要.

关键词:

免疫检查点抑制剂免疫检查点抑制剂免疫治疗是一种免疫疗法.肌肉侵入性膀癌是一种肌肉侵入性膀癌.经期操作性经期操作性尿道膀的新生病.

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