轨道前皮层功能连接的动态变化是晚年抑郁症中嗅觉和认知障碍的基础
Ben Chen1, Shuang Liang1, Ting Su1
1The Affiliated Brain Hospital ,Guangzhou Medical University, Geriatric Neuroscience Center , Guangzhou, China, 510370.
Psychoradiology
|February 20, 2026
概括
随着气味识别缺陷的晚年抑郁症显示了大脑连接的改变. 嗅觉区域的这种动态功能连接可以预测认知能力下降和痴呆风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
背景情况:
- 晚年抑郁症 (LLD) 和嗅觉识别障碍 (OI) 是已知的痴呆症风险因素.
- 连接LLD,OI功能障碍和痴呆风险的神经机制仍然不清楚.
研究的目的:
- 研究具有和没有OI功能障碍的LLD患者的嗅觉大脑区域的动态功能连接 (dFC).
- 检查dFC如何调节LLD中的OI和认知功能之间的关系.
主要方法:
- 休息状态的fMRI数据来自51名LLD患者具有OI缺陷 (LLD-OID),59名LLD患者没有缺陷 (LLD-noOID) 和51名健康对照 (HC).
- 移动窗口分析以估计轨道前皮层 (OFC) 和整个大脑之间的dFC变化.
- 贝叶斯回归和调节分析以评估OFC dFC,OI和认知之间的关联.
主要成果:
- 与LLD-noOID和HC相比,LLD-OID患者表现出OFC-左下额头 (dFC) 的变化性降低,OFC-右中额头 (MFG) 的变化性增加.
- 较高的OFC-MFG变异性与较差的OI和认知表现相关.
- OFC-MFG dFC 变异性显著缓解了 OI 与全球认知之间的关联.
结论:
- 患有OI功能障碍的LLD患者在二级嗅觉区域中表现出受损的dFC.
- 动态OFC-MFG断开连接可能表明LLD患者对认知衰退和痴呆的脆弱性增加.
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