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整合绿色合成和液体-液体提取利多卡因在深深的溶解剂中

Assunta Perri¹, Leonardo C Parrotta¹, Stefania Gencarelli¹

¹Department of Pharmacy, Health and Nutritional Sciences, University of Calabria 87036 Arcavacata of Rende Italy ml.digioia@unical.it.

RSC medicinal chemistry

|February 20, 2026

概括

这项研究介绍了一种可持续的工艺,用于合成使用深度浸泡溶剂 (DES) 的利多卡因. 综合方法减少了浪费,避免了有机溶剂,为活性药物成分 (API) 制造提供了更绿色的方法.

科学领域:

绿色化学绿色化学
制药制造业制药制造业制药制造业
超分子化学超分子化学

背景情况:

开发有效药物成分 (API) 的可持续工艺对于化学工业至关重要.
传统的API合成通常涉及危险的有机溶剂,并产生大量的废物.
由于其可调节的特性和环境效益,深度欧特克溶剂 (DES) 提供了一个有前途的替代品.

研究的目的:

开发一种完全集成和可持续的利多卡因合成工艺.
为了利用深度浸泡溶剂 (DES) 作为反应介质和产品提取.
为了减少API制造对环境的影响.

主要方法:

利多卡因的合成直接在深深的溶解剂中进行.
α-chloro-2,6-dimethylacetanilide的中间形成,然后是S_N2与二甲基胺的反应.
使用疏水性DES用于产品回收的Eutectic-to-eutectic液体-液体提取.

主要成果:

在20分钟内获得中间体的高隔离产量 (92%).
在温和条件下,利多卡因合成的优异产量.
通过GC-MS和FT-IR证实了利多卡因在疏水性DES中的独占分割.
与传统路线相比,减少了工艺质量强度 (PMI) 和溶剂负担.

结论:

深度浸泡溶剂 (DES) 可以有效地作为反应介质,提取剂和配方矩阵.
这种综合工艺为API制造提供了实用和可持续的蓝图.
该方法避免了传统的有机溶剂,增强了工艺的绿色化.

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