转变中的糖尿病前期:德黑兰脂质和葡萄糖研究的见解
Zahra Bahadoran1, Farhad Hosseinpanah2
1Micronutrient Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
健康的生活方式促进糖尿病前期的回归到正常血糖. 肥胖和不良饮食加快了2型糖尿病的进展. 关键因素包括饮食,体力活动和体重管理.
科学领域:
- 代谢健康和内分泌学.
- 流行病学和公共卫生.
- 营养科学. 营养科学.
背景情况:
- 糖尿病前期 (Pre-DM) 是正常血糖和2型糖尿病 (T2D) 之间的中间阶段.
- 预先DM包括异构的表型:孤立的快食葡萄糖受损 (iIFG),孤立的葡萄糖耐受性受损 (iIGT) 和结合的IFG-IGT.
- 了解DM前过渡的决定因素对于预防和管理策略至关重要.
研究的目的:
- 审查来自德黑兰脂质和葡萄糖研究 (TLGS) 的证据,这些证据是关于可修改和不可修改的因素,这些因素影响了DM前的过渡.
- 确定与回归到正常血糖 (NGR) 和进展到T2D相关的决定因素.
- 分析影响DM前结果的表型特异性因素.
主要方法:
- 在PubMed和Scopus中对TLGS出版物的系统文献搜索,截至2025年9月.
- 纳入前性研究,分析DM前的回归和进展.
- 关键词包括"糖尿病前期","禁食葡萄糖受损","葡萄糖耐受性受损","糖尿病","回归","进展","决定因素",以及"德黑兰脂质和葡萄糖研究".
主要成果:
- 回归NGR与年轻年龄,更低的禁食葡萄糖,更高的体力活动和健康饮食有关 (例如,高的替代健康饮食指数 (AHEI) 坚持,低脂肪乳制品,咖啡).
- 进展到T2D与肥胖,中心脂肪,结合IFG-IGT表型和西方风格的饮食有关.
- IGT表型显示体重减轻和健康饮食的回归概率最高;iIFG易受高胆固醇,和/反式脂肪,酸盐/酸盐和等因素的影响.
结论:
- 健康的生活方式因素,包括饮食和体育活动,促进从糖尿病前期回归到正常血糖.
- 肥胖和不健康的饮食模式加快了糖尿病前期到2型糖尿病的进展.
- 基于表型特异性决定因素的有针对性的干预措施可以改善糖尿病前期的管理.
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