Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

3.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.4K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
Diabetic Retinopathy01:27

Diabetic Retinopathy

55
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
55

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Predictors of the early pneumatic displacement effect of submacular haemorrhage secondary to polypoidal choroidal vasculopathy.

Eye (London, England)·2026
Same author

nnLoGoNet: a hybrid local-global network for retinal vessel segmentation with Skeleton Recall Loss.

Scientific reports·2026
Same author

Preoperative Educational Video Viewing is Associated with a Reduced Incidence of Subconjunctival Hemorrhage Following Intravitreal Anti-VEGF Injection.

Patient preference and adherence·2026
Same author

Photochromism <i>via</i> reversible transformation of photoinduced chiral free radicals.

Chemical communications (Cambridge, England)·2026
Same author

MVTT-GMamba: A Multimodal Graph Reasoning Framework for Anti-VEGF Efficacy Prediction in Diabetic Macular Edema.

IEEE journal of biomedical and health informatics·2026
Same author

Targeting STAT5 attenuates retinal neovascularization by promoting apoptosis and suppressing endothelial cell function.

Experimental eye research·2025

相关实验视频

Updated: May 1, 2026

Assessment and Characterization of Hyaloid Vessels in Mice
08:22

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

8.8K

RUNX1通过·维勒布兰德因子促进病态视网膜血管生成.

Ye Liu1,2, Chenfeng He3, Xiaogang Luo1,2

  • 1Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, China.

Advances in ophthalmology practice and research
|February 20, 2026
PubMed
概括

与Runt相关的转录因子1 (RUNX1) 抑制通过调节蛋白质表达,特别是·维勒布兰德因子 (vWF) 来向病态视网膜血管生成. 这项研究揭示了RUNX1在血管生成中的机制,通过vWF轴.

关键词:
这是一种ECM-受体相互作用.抑制了RUNX1的发生.视网膜新血管化疗法·维勒布兰德因素是什么

更多相关视频

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases
06:51

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

4.6K
Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images
04:04

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Published on: May 19, 2023

1.5K

相关实验视频

Last Updated: May 1, 2026

Assessment and Characterization of Hyaloid Vessels in Mice
08:22

Assessment and Characterization of Hyaloid Vessels in Mice

Published on: May 15, 2019

8.8K
Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases
06:51

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

4.6K
Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images
04:04

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

Published on: May 19, 2023

1.5K

科学领域:

  • 眼科医生 眼科 眼科
  • 分子生物学分子生物学
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • 与Runt相关的转录因子1 (RUNX1) 对血管生成至关重要.
  • 药理上抑制RUNX1可以减少病态视网膜血管生成.
  • 在促进血管生成方面,RUNX1的精确蛋白质水平机制尚未完全理解.

研究的目的:

  • 研究RUNX1在促进蛋白质水平上血管生成的功能机制.
  • 为了识别RUNX1的下游蛋白标,参与视网膜病理性血管生成.
  • 评估RUNX1抑制作为视网膜血管生成的治疗策略.

主要方法:

  • 在小鼠中利用氧气诱导视网膜病变 (OIR) 和RUNX1抑制模型.
  • 在数据独立获取 (DIA) 模式下使用液体染色学-并联质谱法 (LC-MS/MS) 分析了视网膜蛋白质组.
  • 进行了体外实验,以评估·维勒布兰德因子 (vWF) 对内皮细胞迁移和发芽的影响.

主要成果:

  • 确定了465种差异表达蛋白 (DEP),其中295种是上调调的,170种是下调调的.
  • 生物信息分析强调了ECM受体相互作用和焦点粘附等途径的丰富.
  • 抑制RUNX1逆转了57种蛋白质的失调,与ECM受体相互作用信号密切相关. ·威尔布兰德因子 (vWF) 被确定为RUNX1.1的下游目标.

结论:

  • RUNX1在视网膜病理性血管生成中发挥着重要作用.
  • RUNX1的亲血管效应通过·维勒布兰德因子 (vWF) 轴介导.
  • RUNX1代表了治疗视网膜病变性血管生成的有前途的治疗标.