肥胖老年人对绿色补充剂的表观遗传和微生物组反应:来自随机交叉控制试验的结果
Laura A Robinson1,2, Aidan M Cavanah1,2, Sarah Lennon1,2
1Department of Nutritional Science, Auburn University, Auburn, AL, United States.
Frontiers in nutrition
|February 20, 2026
概括
这项研究发现,30天的绿色补充剂选择性地改变了成人表观遗传衰老标志物和肠道微生物,但没有影响代谢健康或身体组成. 探索性分析表明,微生物多样性与血糖控制之间存在联系.
科学领域:
- 营养表观遗传学和衰老研究.
- 食补充剂对衰老生物标志物的影响.
- 肠道微生物组和代谢健康相互作用.
背景情况:
- 衰老受遗传,环境和生活方式因素的影响.
- 富含植物化学物质的绿色补充剂可以通过减少炎症和氧化应激来对抗衰老.
- 以前的研究表明,这些补充剂对衰老途径的潜在益处.
研究的目的:
- 为了评估30天的绿色补充剂对表观遗传衰老标志物和代谢健康的影响.
- 评估50-65岁成年肥胖者的DNA甲基化,生物年龄和临床生物标志物的变化.
- 探索绿色补充剂,肠道微生物群多样性和代谢参数之间的关系.
主要方法:
- 一项为期60天的随机交叉设计,涉及21名参与者 (年龄在50-65岁,BMI>30公斤/米2).
- 参与者每天服用绿色蔬菜补充剂30天,主要结果包括表观遗传年龄 (Horvath,PCGrimAge,AdaptAge,DamAge) 和DNA甲基化.
- 二次措施包括代谢生物标志物,微生物群多样性,身体组成和生活质量调查问卷.
主要成果:
- 虽然Horvath表观遗传时钟显示了生物年龄的矛盾增加,但较新的时钟 (AdaptAge, DamAge) 表示了改善的趋势.
- 肠道微生物群的α多样性保持稳定,但像Bilophila和Desulfobacterota这样的特定种群显示出显著的变化.
- 没有观察到身体组成,代谢生物标志物或心理社会措施的显著变化;然而,在微生物多样性和禁食血糖之间发现了反向相关性.
结论:
- 30天的绿色补充剂选择性地改变了肥胖的老年人的表观遗传衰老标志物和肠道微生物组成.
- 补充剂在研究期间没有显著影响整体微生物群多样性,代谢健康或身体组成.
- 探索性发现表明,肠道微生物多样性的变化与绿色补充后改善的血糖控制之间存在潜在联系.
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