相关实验视频

Updated: May 10, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
04:41

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

Published on: July 15, 2010

β-基甲酸减弱了糖化诱导的结构不稳定性和人类血清白蛋白中的氨基基聚合

Hojjat Mohammadnia1, Mousa Bohlooli2, Mansour Ghaffari-Moghaddam1

  • 1Department of Chemistry, University of Zabol, Zabol, Iran.

Biochemistry and biophysics reports
|February 20, 2026
PubMed
概括

葡萄糖诱导的糖化促进蛋白质聚合和粉样蛋白的形成,与神经退行性疾病有关. β-基酸盐 (BHB) 通过稳定蛋白质结构和减少聚合,部分抵消这些影响.

关键词:
高级糖化最终产品的高级糖化.氨基原性途径的发生.原子力显微镜的原子力显微镜.圆形二重化谱光学 圆形二重化谱光学人类血清专素的人类血清专素神经退行发生神经退行.结构稳定 结构稳定这是β-Hydroxybutyrate.

更多相关视频

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation06:34

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

Published on: March 27, 2017

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis06:17

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...