基于功能化氧化改性金纳米颗粒的纳米酶用于组合疗法
Yanfang Hu1, Kaizheng Jia1, Zhijie Guo1
1Xinjiang Key Laboratory of Novel Functional Materials Chemistry, College of Chemistry and Environmental Sciences, Kashi University Kashi 844000 PR China abdukadera@sina.com.
RSC advances
|February 20, 2026
概括
这项研究开发了功能化氧化改性金纳米颗粒 (PIrS@Au) 用于癌症治疗. 这些纳米酶显示出结合瘤治疗的潜力,在暴露于近红外光时抑制癌细胞生长.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 组合疗法是癌症治疗中的一个日益增长的趋势.
- 氧化纳米颗粒由于其光物理化学性质和酶活性,具有瘤治疗的潜力.
- 高功率近红外 (NIR) 激光器通常需要功能化氧化物疗效.
研究的目的:
- 通过将功能化的氧化与黄金纳米粒子结合起来,开发新的纳米酶.
- 评估这些纳米酶 (PIrS@Au) 在抑制癌细胞生长中的有效性.
- 评估PIrS@Au在瘤组合治疗中的潜力.
主要方法:
- 功能化氧化改性金纳米颗粒 (PIrS@Au) 的合成.
- 评估PIrS@Au的特性,包括光热转换效率,光化学活性,类似触酶的活性和生物相容性.
- 在近红外光照射下对HeLa和HepG2细胞的PIrS@Au疗效的体外评估.
主要成果:
- PIrS@Au表现出良好的光热转换效率,光化学活性,类似触酶的活性和生物相容性.
- PIrS@Au被HeLa和HepG2细胞有效地吸收.
- 在NIR照射后观察到显著抑制HeLa和HepG2细胞生长,细胞存活率为35.6%和46.8%在400μg mL-1PIrS@Au.
结论:
- PIrS@Au纳米酶在瘤组合治疗中表现出有前途的潜力.
- 氧化和黄金纳米颗粒的组合提供了增强的治疗能力.
- 对PIrS@Au的进一步研究可能会导致先进的癌症治疗策略.
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