下重建后的骨性死:对生活质量和并发症的比较队列研究
Peng Zhang1, Taiqing Lu2, Ruiyan Gu1
1Department of Prosthodontics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in oncology
|February 20, 2026
概括
与良性或恶性疾病组相比,患有骨质神经衰竭 (ORN) 的患者在下重建后的生活质量明显降低,并发症率更高. 专门的长期护理对于管理ORN挑战至关重要.
科学领域:
- 口腔和牙面部外科手术
- 重建性手术是一种重建性手术.
- 在瘤学瘤学.
背景情况:
- 骨髓硬化 (ORN) 在下重建中提出了独特的挑战.
- 对不同病因 (ORN,恶性,良性) 的结果进行比较对于优化患者护理至关重要.
研究的目的:
- 为了比较纵向生活质量 (QoL) 和细分下巴切除术和自由骨板重建后的外科手术结果.
- 评估ORN患者的QoL和并发症率,与患有恶性或良性疾病的患者相比.
主要方法:
- 一项对245名患者进行的比较队列研究 (45名ORN,160名恶性,40名良性).
- 使用EORTC QLQ-C30和QLQ-H&N35问卷进行手术前和手术后3,6,12个月的评估.
- 主要结局:12个月全球健康状况和疼痛;次要结局:重大手术并发症 (Clavien-Dindo ≥ III).
主要成果:
- 与良性队列相比,12个月后,ORN队列的QoL (较低的全球健康状况,更高的疼痛) 显着更差.
- 在ORN患者中,重大并发症的发生率最高 (48.9%) 和良性并发症 (17.5%).
- 更大的缺陷长度和更长的操作时间预测了更差的QOL和更高的并发症;虚拟手术规划与更好的QOL相关.
结论:
- ORN患者经历了长期的 QoL,持续的疼痛和重建后更高的并发症负担.
- 调查结果强调了ORN管理的独特挑战.
- 专业的长期支持性护理对ORN患者至关重要.
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