在前列腺癌中推进CAR-T疗法:克服瘤微环境并提高疗效
Zhongze Zhou1,2, Yongfeng Lao1,2, Kun Zhao1,2
1Department of Urology, Second Hospital of Lanzhou University, Lanzhou, Gansu, China.
Frontiers in oncology
|February 20, 2026
概括
化学抗原受体T (CAR-T) 疗法在晚期前列腺癌 (PCa) 中表现有前途. 在CAR工程和组合治疗方面的创新旨在克服诸如有限抗原和免疫抑制等挑战,以获得更有效的PCa疗法.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症研究 癌症研究
背景情况:
- 前列腺癌 (PCa) 是男性常见的恶性瘤,对转移性割耐药PCa (mCRPC) 的选择有限.
- 化学抗原受体T (CAR-T) 疗法在血液癌症中取得了成功,但由于瘤抗原稀缺,免疫抑制性瘤微环境 (TME),抗原异质性以及细胞因子释放综合征等安全问题,在PCa方面面临挑战.
研究的目的:
- 提供关于前列腺癌中CAR-T治疗的综合文献综述.
- 总结PCa特定的CAR目标,TME相关的障碍和技术挑战.
- 突出最近在CAR工程和PCa的组合疗法的进展.
主要方法:
- 关于前列腺癌中CAR-T疗法应用的综合文献综述.
- 分析已知的PCa特定CAR目标和识别的障碍.
- 关于CAR工程 (例如,装甲CAR-T,基因编辑) 和组合策略的进展概述.
主要成果:
- 新兴的策略,包括下一代CAR设计 (例如,细胞因子武装的CAR-T) 和代谢重编程,显示出克服TME相关障碍的潜力.
- 调节瘤代谢和免疫检查点可以逆转T细胞枯竭,而多抗原CAR和基因编辑可以减轻抗原逃逸.
- 早期的临床试验表明,CAR-T细胞可以识别前列腺相关的抗原,并引起抗瘤反应,尽管持久的缓解很少发生.
结论:
- 前列腺癌的CAR-T疗法是一个快速发展的领域.
- 在CAR设计中的创新,如装甲CAR-T细胞和多抗原向,对于提高疗效至关重要.
- 结合方法和正在进行的研究有望开发更有效和更持久的CAR-T治疗先进PCa.
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