尽管计数正常化,但持续的中性粒细胞激活表明,在运动热中风时,免疫系统失调
Yue Wang1,2, Siya Xu3, Zhongzhi Tang3
1Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China.
Frontiers in immunology
|February 20, 2026
概括
中性粒细胞激活在运动性热中风 (EHS) 患者中持续存在,即使中性粒细胞数量正常化后. 持久性髓氧化酶 (MPO) 和中性粒细胞弹性酶 (NE) 表明长时间的中性粒细胞失调,可能导致组织损伤.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 环境健康 环境健康
背景情况:
- 强迫性热中风 (EHS) 是一种危及生命的疾病,涉及全身炎症.
- 中性粒细胞在EHS病理生理学中的特定作用尚不清楚.
- 这项研究调查了中性粒细胞在EHS期间的行为.
研究的目的:
- 描述中性粒细胞招募和激活中性粒细胞的纵向变化.
- 为了比较与中性粒细胞相关的标志物在EHS患者与健康对照随着时间的推移.
主要方法:
- 对18名EHS患者和18名匹配的对照进行了回顾性分析.
- 血清样本通过ELISA分析IL-6,IL-8,IL-17,G-CSF,CXCL1,CXCL2,CRP,SAA,MPO和NE在基线和治疗后的3,5和7天.
主要成果:
- 在开始时,EHS患者表现出中性恋和升高的IL-8,CXCL1,CXCL2和IL-17.
- 中性粒细胞数量在几天内正常化,但MPO和NE在治疗后7天内仍然显著升高.
- 在疾病发病时CXCL1/CXCL2和MPO/NE水平之间发现了强烈的正相关性.
结论:
- 在EHS中,中性粒细胞的招募和激活之间存在分离.
- 持续高水平的MPO和NE表明中性粒细胞在EHS后的长期失调.
- 这种失调可能会导致急性组织损伤和长期免疫问题,在EHS幸存者.
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