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Updated: Feb 22, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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肝硬化中的PBPK建模的综合病理生理学库:量化持续的疾病进展和人口变异性

Annika R P Schneider1,2, Vanessa Baier1,3, Jan-Frederik Schlender2,4

  • 1Institute of Applied Microbiology - iAMB, Aachen Biology and Biotechnology - ABBt, RWTH Aachen University, Aachen, Germany.

CPT: pharmacometrics & systems pharmacology
|February 20, 2026
PubMed
概括

这项研究开发了肝硬化患者生理变化的全面存储库. 本资源增强了药理动力学 (PK) 建模,改善了药物开发和临床试验设计,用于这种复杂的患者群体.

关键词:
儿童-普赫评分 儿童-普赫评分在 PBPK 建模中使用 PBPK 模型.肝功能受损 肝功能受损肝硬化是肝硬化的一种疾病.药物动力学 药物动力学

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