在normosmic个体的嗅觉训练后,嗅觉球体体积的变化
I Torvik Heian1,2,3, A-S Helvik4,5, T Å Myklebust3
1Institute of Neuromedicine and Movement Science (INB), Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Rhinology
|February 20, 2026
概括
嗅觉训练 (OT) 在正常人群中增加了嗅觉球体体积 (OBV),这种效应持续了很长一段时间. 然而,这种结构变化并没有改善嗅觉功能.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉研究 嗅觉研究
- 神经成像是一种神经成像.
背景情况:
- 嗅觉训练 (OT) 与嗅觉功能变化和嗅觉球体 (OB) 结构变化有关.
- 在OT之后的OB内的神经可塑性潜力需要进一步调查.
- 这项试点研究研究了不同OT持续时间对Normosmic个体的OB体积和嗅觉功能的影响.
研究的目的:
- 为了研究嗅觉训练对嗅觉球体体积的神经可塑性影响.
- 为了比较标准与延长的嗅觉训练持续时间的影响.
- 评估嗅觉功能的变化与嗅觉球泡体积的变化有关.
主要方法:
- 77个正常的个体参与了为期三个月的干预.
- 参与者被分配到标准OT (40秒/天),延长OT (4分钟/天) 或对照组.
- 嗅觉球体体积 (MRI) 和嗅觉功能 (Sniffin' Sticks) 在基线,干预后和一年后的随访中进行了评估.
主要成果:
- 与对照组相比,标准和扩展的OT组都显示了OBV的显著增加.
- 在标准和扩展的OT方法之间没有观察到OBV变化的显著差异.
- 干预组中没有检测到嗅觉功能的显著改善.
结论:
- 嗅觉训练,无论持续时间如何,都会导致Normosmic个体的OBV的快速和持续增加.
- 由OT引起的OBV的神经塑性变化可以延伸到训练期之外.
- 观察到的OBV增加与嗅觉功能的改善没有相关性.
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