循环体和事件心血管结果和死亡率:来自英国生物银行的见解
Parag Anilkumar Chevli1, Saeid Mirzai1, Richard Kazibwe2
1Department of Cardiovascular Medicine Wake Forest University School of Medicine Winston-Salem NC USA.
较高的体 (KB) 与心血管事件和死亡率的风险增加有关. 这项针对大量人群的研究发现,高KB水平与较高的动脉样硬化心血管疾病 (ASCVD),心力衰竭 (HF) 和死亡率相关.
科学领域:
- 心血管医学 心血管医学
- 代谢健康 代谢健康
- 生物化学 生物化学
背景情况:
- 体 (KB) 是肝脏在代谢应激过程中产生的重要内源能量来源.
- KB对动脉样硬化心血管疾病 (ASCVD),心力衰竭 (HF) 和死亡率的确切影响尚不清楚.
- 这项研究调查了在没有先前存在的ASCVD或HF的一般人群中,KB水平和新的心血管结果之间的关系.
研究的目的:
- 确定内源体水平与心血管疾病 (CVD) 和死亡率的发生率之间的关联.
- 分析特定心血管事件的风险,包括ASCVD,HF,心肌梗塞和中风,与KB水平相关.
- 评估 KB 与所有原因死亡率和心血管死亡的关联.
主要方法:
- 利用了来自英国生物库的90,987名参与者的数据,他们都没有流行ASCVD或HF.
- 使用核磁共振光谱学测量了总体 (KB).
- 采用多变量调整的考克斯比例危险模型来评估KB与主要结果 (ASCVD,HF,全因死亡) 和二次结果之间的关联,平均随访时间为13.4年.
主要成果:
- 较高的体 (KB) 水平与发生动脉样硬化心血管疾病 (ASCVD) (HR, 1.31),心力衰竭 (HF) (HR, 1.44) 和全因死亡率 (HR, 1.51) 每增加10倍的风险显著增加.
- 随着KB水平的提高,中风 (37%) 和心血管疾病 (CVD) 死亡 (69%) 的风险显著增加.
- 在KB水平和心肌梗塞发病率之间没有发现显著的关联.
结论:
- 在没有基线心血管疾病 (CVD) 的个人中,内源性体 (KB) 的升高与患ASCVD,HF和中风的风险更高有关.
- 高KB水平与全因死亡率和心血管疾病死亡风险增加有关.
- 这些发现突出了KB在心血管风险分层和管理中的潜在作用.
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