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评估在骨关节炎试验中使用历史性安慰剂控制的可行性

Justine Monseur1, Emma Barbeau1, Anne-Françoise Donneau1

  • 1Research Unit Public Health, From Biostatistics to Health Promotion, University of Liège, 4000 Liège, Belgium.

Epidemiologia (Basel, Switzerland)
|February 20, 2026
PubMed
概括

在骨关节炎 (OA) 随机对照试验 (RCT) 中用实时数据取代历史的安慰剂数据是不可行的. 即使使用先进的匹配技术,安慰剂反应仍然存在显著差异,这限制了在OA研究中使用历史对照的可能性.

关键词:
骨关节炎是一种关节炎.果 果 果 果随机对照试验是随机对照试验.

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