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血管造影衍生的定量流量比率的诊断性能:系统性审查和元分析

Guo Huang^1,2, Pu Ge³, He Zhu^1,2

¹Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Medical sciences (Basel, Switzerland)

|February 20, 2026

概括

定量流量比 (QFR) 准确地评估冠状动脉狭窄的意义,为侵入性微分流量储备 (FFR) 提供了替代方案. 基于穆雷定律的QFR (μQFR) 在此元分析中显示了最高的诊断性能.

科学领域:

心脏病学心脏病学
医疗成像医学成像
诊断性表现诊断性表现

背景情况:

定量流量比 (QFR) 是一种基于血管造影的新技术,用于评估冠状动脉狭窄的功能意义.
QFR旨在作为侵入性分流储备 (FFR) 评估的非侵入性替代方案.
目前对QFR的证据有限,需要对其诊断能力进行全面评估.

研究的目的:

系统地确定QFR的诊断性能,以识别功能显著的冠状动脉狭窄症.
为了将QFR的精度与侵入性FFR进行比较,建立了参考标准.
评估不同的QFR方法,并确定最有效的方法.

主要方法:

一个系统的审查和对评估血管学衍生QFR系统的研究的元分析.
从六个文献数据库中包含了57项研究,包括13,215名患者和16,125个血管.
使用DerSimonian-Laird方法计算聚合的灵敏度,特异性,概率比率和诊断几率比率 (DOR).

主要成果:

QFR表现出强大的诊断性能,聚合灵敏度为0.826和特异性为0.919.
总结接收器操作特征曲线 (AUC) 下的总面积为0.94,表明高精度.
基于穆雷定律的QFR (μQFR) 在评估模式中表现出最高的诊断性能 (AUC 0.97,调整后聚合DOR 126.25).

结论:

血管造影衍生QFR是一种非常准确的工具,用于评估冠状动脉狭窄症的功能意义.
QFR作为一种可靠的非侵入性替代入侵性FFR.
μQFR代表了目前可用于临床应用的最有效的QFR方法.

关键词:

血管造影 - 血管造影部分流量储备部分流量储备量化流量比率量化流量比率有显著的狭窄性.

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