微生物组-代谢组交叉作为COVID-19严重程度的驱动因素
Patricia Diez-Echave1, María Jesús Rodríguez-Sojo1,2, Benita Martin-Castaño2,3
1Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071 Granada, Spain.
COVID-19的严重程度与肠道细菌和代谢物有关. 特定的微生物和改变的代谢途径与疾病严重程度相关,为管理COVID-19进展提供潜在的生物标志物和治疗点.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 免疫学 免疫学 免疫学
背景情况:
- COVID-19 (冠状病毒疾病2019) 严重程度差异很大,传统的风险因素不足以解释这种异质性.
- 肠道微生物群和宿主代谢学可能在调节免疫反应和疾病结果方面发挥关键作用.
- 了解这些相互作用对于开发有效的COVID-19治疗非常重要.
研究的目的:
- 调查COVID-19患者肠道微生物群变异和血代谢物概况之间的关联.
- 探索微生物和代谢特征与COVID-19疾病严重程度之间的关系.
- 为了确定调节COVID-19进展的潜在治疗点.
主要方法:
- 55名COVID-19患者的前性队列研究.
- 使用16SrRNA测序来分析肠道微生物群的便和血样本.
- 无向液体染色学-高分辨率质谱 (LC-HRMS) 用于血代谢学.
主要成果:
- 严重的COVID-19病例显示微生物多样性降低和促炎性类型的丰富 (例如Prevotella,Alistipes).
- 轻度病例中,有较高的保护性共生体 (例如,Bacteroides,Faecalibacterium) 和不同的代谢物 (例如,乙卡尼丁,伊诺西衍生物) 样本.
- 严重病例中临床酸水平升高与促炎性微生物相关;微生物代谢预测了与炎症相关的途径.
结论:
- 肠道微生物群的组成和循环中的代谢物与COVID-19的严重程度有很大关系.
- 已识别的微生物和代谢学特征显示出疾病进展的潜在生物标志物.
- 这些签名可能作为调节COVID-19结果的治疗点.
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